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BDBM310881 3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide::US10150767, Example 21

SMILES: Cn1cc(-c2cccc(c2)C(N)=O)c2cc[nH]c2c1=O

InChI Key: InChIKey=ZHSINCQZRRZNPK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310881   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310881
PNG
(3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)be...)
Show SMILES Cn1cc(-c2cccc(c2)C(N)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C15H13N3O2/c1-18-8-12(11-5-6-17-13(11)15(18)20)9-3-2-4-10(7-9)14(16)19/h2-8,17H,1H3,(H2,16,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair