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BDBM310884 4-[4-(3-fluoroazetidine-1-carbonyl)phenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10150767, Example 27

SMILES: Cn1cc(-c2ccc(cc2)C(=O)N2CC(F)C2)c2cc[nH]c2c1=O

InChI Key: InChIKey=LZEZGXBLBKUAKG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310884   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310884
PNG
(4-[4-(3-fluoroazetidine-1-carbonyl)phenyl]-6-methy...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CC(F)C2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H16FN3O2/c1-21-10-15(14-6-7-20-16(14)18(21)24)11-2-4-12(5-3-11)17(23)22-8-13(19)9-22/h2-7,10,13,20H,8-9H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 84n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair