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BDBM310887 4-[4-(4-acetylpiperazine-1-carbonyl)phenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10150767, Example 32

SMILES: Cn1cc(-c2ccc(cc2)C(=O)N2CCN(CC(N)=O)CC2)c2cc[nH]c2c1=O

InChI Key: InChIKey=OZTPACWIZDHYCN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310887   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310887
PNG
(4-[4-(4-acetylpiperazine-1-carbonyl)phenyl]-6-meth...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CCN(CC(N)=O)CC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H23N5O3/c1-24-12-17(16-6-7-23-19(16)21(24)29)14-2-4-15(5-3-14)20(28)26-10-8-25(9-11-26)13-18(22)27/h2-7,12,23H,8-11,13H2,1H3,(H2,22,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 320n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair