BDBM310966 US10155727, Example 20::USRE49517, Example 20
SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(F)c(OC(F)F)c1
InChI Key InChIKey=IGIJOLSYMZJTQD-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 310966
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Pharmaceuticals
US Patent
Janssen Pharmaceuticals
US Patent
Affinity DataIC50: 22.2nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals
US Patent
Janssen Pharmaceuticals
US Patent
Affinity DataIC50: 2.26E+4nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals
US Patent
Janssen Pharmaceuticals
US Patent
Affinity DataIC50: 22.2nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
Affinity DataIC50: 5.97E+3nMAssay Description:The medium was removed and the cells were loaded with 200 μl loading buffer (Molecular Devices) in Mg2+-free HBPS containing 100 μM 7-CKA a...More data for this Ligand-Target Pair