BDBM31121 5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14

SMILES CCOC(=O)c1c(Nc2cccc(Cl)c2)[nH]c2c1cc(O)c1ccccc21

InChI Key InChIKey=VFNRZHHIOIJKGR-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 31121   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31121(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14)
Affinity DataIC50:  240nM EC50:  710nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31121(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31121(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cells assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed