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BDBM311222 (S)-1-((3-chloro-5-(quinolin-4-yl)pyridin-2-yl)oxy)-2,4-dimethylpentan-2-amine::US10155760, Example 78

SMILES: CC(C)C[C@](C)(N)COc1ncc(cc1Cl)-c1ccnc2ccccc12

InChI Key: InChIKey=IGJJATQUVSNMJD-NRFANRHFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311222   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AP2-associated protein kinase 1


(Homo sapiens)
BDBM311222
PNG
((S)-1-((3-chloro-5-(quinolin-4-yl)pyridin-2-yl)oxy...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1Cl)-c1ccnc2ccccc12
Show InChI InChI=1S/C21H24ClN3O/c1-14(2)11-21(3,23)13-26-20-18(22)10-15(12-25-20)16-8-9-24-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,23H2,1-3H3/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 0.490n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10155760 (2018)

More data for this
Ligand-Target Pair