BindingDB logo
myBDB logout

BDBM311382 (S)-1-((4-chloro-6-(6-chloroquinolin-4-yl)pyridin-3-yl)oxy)-2,4-dimethylpentan-2-amine::US10155760, Example 239

SMILES: CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(Cl)cc12

InChI Key: InChIKey=SDPZRFIRDDBFJR-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311382   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311382
PNG
((S)-1-((4-chloro-6-(6-chloroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(Cl)cc12
Show InChI InChI=1S/C21H23Cl2N3O/c1-13(2)10-21(3,24)12-27-20-11-26-19(9-17(20)23)15-6-7-25-18-5-4-14(22)8-16(15)18/h4-9,11,13H,10,12,24H2,1-3H3/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.390n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10155760 (2018)


BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair