BDBM31148 3-hydroxyquinolin-2(1H)-one, 2::US9701638, 1

SMILES Oc1cc2ccccc2[nH]c1=O

InChI Key InChIKey=BERPCVULMUPOER-UHFFFAOYSA-N

Data  10 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 31148   

TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetD-aspartate oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  855nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-aspartic acid was linke...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataKd:  13nMAssay Description:Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  215nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Sus scrofa (pig))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  100nMAssay Description:Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  42nMAssay Description:Inhibition of DAAO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
TargetHemagglutinin(Influenza A virus (strain swl A/California/04/2009...)
Rutgers, The State University Of New Jersey

US Patent
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  2.40E+4nMpH: 7.5Assay Description:The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Sus scrofa (pig))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataKd:  150nMAssay Description:Binding affinity to pig kidney DAAO by ITC methodMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  94nMAssay Description:Inhibition of rat spinal DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed