BDBM31150 3-hydroxyquinolin-2(1H)-one, 4

SMILES Oc1cc2ccc(F)cc2[nH]c1=O

InChI Key InChIKey=DIUYMCVADDVTRZ-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 31150   

TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31150(3-hydroxyquinolin-2(1H)-one, 4)
Affinity DataIC50:  10nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31150(3-hydroxyquinolin-2(1H)-one, 4)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31150(3-hydroxyquinolin-2(1H)-one, 4)
Affinity DataKd:  38nMAssay Description:Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31150(3-hydroxyquinolin-2(1H)-one, 4)
Affinity DataIC50:  2.24E+4nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-aspartic acid was linke...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed