BDBM312089 3-(7-fluoronaphthanlen- 1-yl)pyrrolidine-2,5- dione::US9603836, Compound 25::US9949951, 25

SMILES Fc1ccc2cccc(C3CC(=O)NC3=O)c2c1

InChI Key InChIKey=VRIMRXAAUXFFOF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 312089   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312089(3-(7-fluoronaphthanlen- 1-yl)pyrrolidine-2,5- dion...)
Affinity DataIC50:  4.60E+3nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312089(3-(7-fluoronaphthanlen- 1-yl)pyrrolidine-2,5- dion...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312089(3-(7-fluoronaphthanlen- 1-yl)pyrrolidine-2,5- dion...)
Affinity DataIC50:  4.60E+3nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent