BindingDB logo
myBDB logout

BDBM312591 1-[4-(8-Butoxy-6-ethoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine::US9604989, Example 77

SMILES: CCCCOc1cc(OCC)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1

InChI Key: InChIKey=LBOORVCNXGUHCT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312591   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312591
PNG
(1-[4-(8-Butoxy-6-ethoxy-3-phenylimidazo[1,2-b]pyri...)
Show SMILES CCCCOc1cc(OCC)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C28H32N4O2/c1-3-5-18-34-23-19-24(33-4-2)31-32-26(21-10-7-6-8-11-21)25(30-27(23)32)20-12-14-22(15-13-20)28(29)16-9-17-28/h6-8,10-15,19H,3-5,9,16-18,29H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312591
PNG
(1-[4-(8-Butoxy-6-ethoxy-3-phenylimidazo[1,2-b]pyri...)
Show SMILES CCCCOc1cc(OCC)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C28H32N4O2/c1-3-5-18-34-23-19-24(33-4-2)31-32-26(21-10-7-6-8-11-21)25(30-27(23)32)20-12-14-22(15-13-20)28(29)16-9-17-28/h6-8,10-15,19H,3-5,9,16-18,29H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair