BDBM312633 US9604998, Example 33::US9604998, Example 41

SMILES COc1c(F)c(ccc1C(O)CN1CCN2C[C@H](OC[C@H]2C1)c1ccc2C(=O)OCc2c1C)C#N

InChI Key InChIKey=KKBYIDICHVWAHQ-HWOJSTDLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312633   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312633(US9604998, Example 33 | US9604998, Example 41)
Affinity DataIC50:  140nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312633(US9604998, Example 33 | US9604998, Example 41)
Affinity DataIC50:  170nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent