BDBM312638 US9604998, Example 38::US9604998, Example 49

SMILES Cc1c2COC(=O)c2ccc1[C@@H]1CN2CCN(CC(O)c3cc(F)c(C#N)c(F)c3)C[C@H]2CO1

InChI Key InChIKey=NJDJLIVMHJXUFE-VHWFRIBGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312638   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312638(US9604998, Example 38 | US9604998, Example 49)
Affinity DataIC50:  50nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312638(US9604998, Example 38 | US9604998, Example 49)
Affinity DataIC50:  120nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent