BDBM312698 US9604998, Example 97

SMILES COc1cc(CCN2CCN3C[C@@H](OC[C@H]3C2)c2ccc3C(=O)OCc3c2C)c(F)cc1C#N

InChI Key InChIKey=NBSAMMNMVMZTKK-KBMIEXCESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312698   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312698(US9604998, Example 97)
Affinity DataIC50:  280nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent