BDBM312792 5-cyclopropyl-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2-oxo- pyrrolidin-3-yl]ethynyl]- 2-pyridyl]pyrazole-3-carbox- amide::US9605005, Example 81

SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(cc2C2CC2)C(N)=O)C1=O

InChI Key InChIKey=WFIYKEJGYKFLJS-IBGZPJMESA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 312792   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM312792(5-cyclopropyl-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2-...)
Affinity DataKi:  15.8nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM312792(5-cyclopropyl-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2-...)
Affinity DataKi:  16nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM312792(5-cyclopropyl-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed