BDBM312845 6-cyano-1-[3-[2-[(7S)-7-hy- droxy-5,6-dihydrocyclopen- ta[b]pyridin-7-yl]ethynyl]phe- nyl]pyrazolo[4,3-c]pyridine- 3-carboxamide::US9605005, Example 135

SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@@]2(O)CCc3cccnc23)c2cc(ncc12)C#N

InChI Key InChIKey=AHGTWOKJRDCXGS-XMMPIXPASA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312845   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM312845(6-cyano-1-[3-[2-[(7S)-7-hy- droxy-5,6-dihydrocyclo...)
Affinity DataKi:  0.700nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent