BDBM313500 N-(3-(5-(3- hydroxyoxetan-3-yl)-6- ((tetrahydro-2H-pyran- 4-yl)oxy)pyridin-3-yl)- 4-methylphenyl)-3- (trifluoromethyl)benzamide::US10167279, Example 119

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)C1(O)COC1

InChI Key InChIKey=DTHMVQCNWFKXRR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313500   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313500(N-(3-(5-(3- hydroxyoxetan-3-yl)-6- ((tetrahydro-2H...)
Affinity DataIC50:  808nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313500(N-(3-(5-(3- hydroxyoxetan-3-yl)-6- ((tetrahydro-2H...)
Affinity DataIC50:  176nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent