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BDBM314095 US9610322, 6a (cis olefin)

SMILES: NC(=C)CC[C@@H]1NC(=O)\C=C\C(=O)N[C@H](CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O

InChI Key: InChIKey=OPIMKBVXMOFIMR-BNZWSXBXSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 314095   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme


(Homo sapiens (Human))
BDBM314095
PNG
(US9610322, 6a (cis olefin))
Show SMILES NC(=C)CC[C@@H]1NC(=O)\C=C\C(=O)N[C@H](CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O
Show InChI InChI=1S/C43H55N5O7/c1-28(44)17-22-34-38(50)27-33(25-29-11-5-2-6-12-29)43(55)48-36(26-30-18-20-32(21-19-30)41(53)31-13-7-3-8-14-31)37(49)16-10-4-9-15-35(42(45)54)47-40(52)24-23-39(51)46-34/h3,7-8,13-14,18-21,23-24,29,33-36H,1-2,4-6,9-12,15-17,22,25-27,44H2,(H2,45,54)(H,46,51)(H,47,52)(H,48,55)/b24-23+/t33-,34+,35-,36?/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60E+3n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...


US Patent US9610322 (2017)

More data for this
Ligand-Target Pair