BDBM315831 US10172859, Example 252::US10172859, Example 253::US10172859, Example 267::US11065253, Example 267::US9732094, Example 267::[4-Fluoro-3-(5-fluoro- 7-morpholin-4-yl- quinazolin-4-yl)- phenyl]-(3-methoxy- pyrazin-2-yl)- methanol (Ena 2)see racemate

SMILES COc1nccnc1C(O)c1ccc(F)c(c1)-c1ncnc2cc(cc(F)c12)N1CCOCC1

InChI Key InChIKey=MBESFUDQRFVLFJ-UHFFFAOYSA-N

Data  6 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 315831   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50:  18.5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50:  19nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50:  18.5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315831(US10172859, Example 252 | US10172859, Example 253 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent