BDBM31652 imidazole-dioxolane, 3

SMILES Clc1ccc(CC[C@@]2(Cn3ccnc3)OC[C@@H](CSc3ccccc3)O2)cc1

InChI Key InChIKey=RZJAKIZOPWLXJW-RBBKRZOGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 31652   

TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31652(imidazole-dioxolane, 3)
Affinity DataIC50:  1.03E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31652(imidazole-dioxolane, 3)
Affinity DataIC50:  2.00E+3nMAssay Description:CYP3A1/3A2-catalyzed erythromycin N-demethylase activity was determined by the spectrophotometric measurement of formaldehyde. Briefly, reaction mixt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31652(imidazole-dioxolane, 3)
Affinity DataIC50:  3.40E+4nMpH: 7.4Assay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31652(imidazole-dioxolane, 3)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed