BDBM316985 N-[2,4-Difluoro-3-(4-methyl- 7H-pyrrolo[2,3-d]pyrimidine- 5-carbonyl)-phenyl]-3-fluoro- 4-methoxy- benzenesulfonamide::US9617267, Compound P-1036

SMILES COc1ccc(cc1F)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncnc(C)c23)c1F

InChI Key InChIKey=MABAIMZGUCLCLC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 316985   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316985(N-[2,4-Difluoro-3-(4-methyl- 7H-pyrrolo[2,3-d]pyri...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316985(N-[2,4-Difluoro-3-(4-methyl- 7H-pyrrolo[2,3-d]pyri...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316985(N-[2,4-Difluoro-3-(4-methyl- 7H-pyrrolo[2,3-d]pyri...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent