BDBM316991 N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2,3-d]pyrimidine-5- carbonyl)-phenyl]-4-ethyl- benzenesulfonamide::US9617267, Compound P-1042

SMILES CCc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncnc(NC(C)C)c23)c1F

InChI Key InChIKey=ZWORQWXQCWAORP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 316991   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM316991(N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2...)
Affinity DataIC50:  7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent