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BDBM31700 (5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one::5-(5-bromo-2-methoxy-benzylidene)-2-(2-furyl)thiazolo[3,2-b][1,2,4]triazol-6-one::5-[(5-bromanyl-2-methoxy-phenyl)methylidene]-2-(furan-2-yl)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one::5-[(5-bromo-2-methoxyphenyl)methylidene]-2-(2-furanyl)-6-thiazolo[3,2-b][1,2,4]triazolone::5-[(5-bromo-2-methoxyphenyl)methylidene]-2-(furan-2-yl)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one::MLS000043560::SMR000020576::cid_3236807
SMILES: COc1ccc(Br)cc1C=c1sc2nc(nn2c1=O)-c1ccco1
InChI Key: InChIKey=ADCWLBBZUYYUKS-JYRVWZFOSA-N
Data: 25 IC50
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heat Shock 70kDa Protein 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 7.0 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Burnham Center for Chemical Genomics (BCCG) Burnham Institute for Medical Research (San Diego, CA) NIH Molecular Libraries Screening Centers Network ... | PubChem Bioassay (2008) Article DOI: 10.1016/S0893-133X(98)00099-2 BindingDB Entry DOI: 10.7270/Q2S180TW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.09E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DF6PNW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 1.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi... | PubChem Bioassay (2006) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20863PV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 1.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1... | PubChem Bioassay (2006) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2VH5M71 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit... | PubChem Bioassay (2006) Article DOI: 10.1111/cbdd.12105 BindingDB Entry DOI: 10.7270/Q2QR4VH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| MKP-3 (Rattus norvegicus) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2H70D6B | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat Shock 70kDa Protein 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2RF5SF5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 1.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ... | PubChem Bioassay (2007) Article DOI: 10.1021/cc100073a BindingDB Entry DOI: 10.7270/Q29K48M5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2... | PubChem Bioassay (2007) Article DOI: 10.1021/cc100076k BindingDB Entry DOI: 10.7270/Q25T3HWF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| MKP-3 (Rattus norvegicus) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3... | PubChem Bioassay (2006) Article DOI: 10.1021/cb300729y BindingDB Entry DOI: 10.7270/Q2M043S8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| MKP-3 (Rattus norvegicus) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit... | PubChem Bioassay (2007) Article DOI: 10.1021/cc050016r BindingDB Entry DOI: 10.7270/Q2G73C2Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Genome polyprotein (West Nile virus) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776... | PubChem Bioassay (2007) Article DOI: 10.1021/co200147y BindingDB Entry DOI: 10.7270/Q2222S6W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni... | PubChem Bioassay (2006) Article DOI: 10.1021/cc0501561 BindingDB Entry DOI: 10.7270/Q2BG2MCP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2X928QK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2SJ1J08 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2NS0S8J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 2.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2J101KZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| MKP-3 (Rattus norvegicus) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2DB806H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 7.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q28K77GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity phosphatase Cdc25B (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2125R2H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hematopoietic protein-tyrosine phosphatase (HEPTP) (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2008) Article DOI: 10.1021/cb3006165 BindingDB Entry DOI: 10.7270/Q2RJ4GWX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| heat shock 70kDa protein 8 isoform 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PCBioAssay | n/a | n/a | 9.99E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen... | PubChem Bioassay (2007) Article DOI: 10.1021/cb400371r BindingDB Entry DOI: 10.7270/Q2MS3R62 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| core protein (Hepatitis C virus) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | >4.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q29Z939R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2J67FCM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human)) | BDBM31700 ((5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
University of Pittsburgh Curated by PubChem BioAssay | Assay Description The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2F769WQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
