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BDBM317372 US9617282, Example 145

SMILES: O=C1Nc2cn(CCN3CCNCC3)nc2C(=O)NCCOCCNc2cc(ccn2)-c2nc1cs2

InChI Key: InChIKey=JQONLTPYFXNWAQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317372   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317372
PNG
(US9617282, Example 145)
Show SMILES O=C1Nc2cn(CCN3CCNCC3)nc2C(=O)NCCOCCNc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C23H29N9O3S/c33-21-18-15-36-23(29-18)16-1-2-25-19(13-16)26-5-11-35-12-6-27-22(34)20-17(28-21)14-32(30-20)10-9-31-7-3-24-4-8-31/h1-2,13-15,24H,3-12H2,(H,25,26)(H,27,34)(H,28,33)
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MMDB

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PC cid
PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair