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BDBM317382 US9617282, Example 155

SMILES: O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCC3CCNCC3)nc12

InChI Key: InChIKey=ZVGFTSIVVDJTLK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317382   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317382
PNG
(US9617282, Example 155)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCC3CCNCC3)nc12
Show InChI InChI=1S/C24H29N7O4S/c32-22-19-15-36-24(29-19)17-3-7-26-20(13-17)35-12-11-34-10-8-27-23(33)21-18(28-22)14-31(30-21)9-4-16-1-5-25-6-2-16/h3,7,13-16,25H,1-2,4-6,8-12H2,(H,27,33)(H,28,32)
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PC cid
PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair