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BDBM317395 US9617282, Example 168

SMILES: O=C1NCCNCCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1

InChI Key: InChIKey=IZWGIJDOSIGHDL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317395   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317395
PNG
(US9617282, Example 168)
Show SMILES O=C1NCCNCCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C23H27N7O3S/c31-21-19-14-34-23(28-19)15-3-7-25-16(12-15)2-1-6-24-8-9-26-22(32)20-18(27-21)13-30(29-20)17-4-10-33-11-5-17/h3,7,12-14,17,24H,1-2,4-6,8-11H2,(H,26,32)(H,27,31)
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MMDB

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PC cid
PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair