BDBM317712 US11337976, Compound P-0083::US20230277534, Compound P-0083::US9624213, Compound P-0083

SMILES COc1ncc(cn1)-c1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)N(C)CC4CC4)c3F)c2c1

InChI Key InChIKey=GCYSURGZPZJTPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 317712   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317712(US11337976, Compound P-0083 | US20230277534, Compo...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317712(US11337976, Compound P-0083 | US20230277534, Compo...)
Affinity DataIC50: <100nMAssay Description:The biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, where inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317712(US11337976, Compound P-0083 | US20230277534, Compo...)
Affinity DataIC50: <100nMAssay Description:For example, the biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent