BDBM318461 7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one::US10464947, Example 6::US11498926, Example 6::US9624241, Example 6

SMILES COc1cccc(c1)C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318461   

TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318461(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318461(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [353-454](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318461(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Affinity DataIC50: <100nMAssay Description:Table 12: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318461(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [58-164](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318461(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Affinity DataIC50: <100nMAssay Description:Table 11: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM318461(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent