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BDBM318507 7-(3,5-Dimethylisoxazol-4-yl)-4-(5-fluoropyridin-2-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one::US9624241, Example 19

SMILES: Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cn1

InChI Key: InChIKey=IGERAFAXUIXTAP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 318507   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318507
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(5-fluoropyridin-2...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cn1
Show InChI InChI=1S/C19H15FN4O3/c1-9-16(10(2)27-23-9)12-4-6-14-17-18(12)26-8-15(24(17)19(25)22-14)13-5-3-11(20)7-21-13/h3-7,15H,8H2,1-2H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318507
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(5-fluoropyridin-2...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cn1
Show InChI InChI=1S/C19H15FN4O3/c1-9-16(10(2)27-23-9)12-4-6-14-17-18(12)26-8-15(24(17)19(25)22-14)13-5-3-11(20)7-21-13/h3-7,15H,8H2,1-2H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair