BDBM318664 (4S)-7-(3,5-dimethylisoxazol-4-yl)-2- [(8aS)-hexahydropyrrolo[1,2-a]pyrazin- 2(1H)-yl]-4-pyridin-2-yl-4,5- dihydroimidazo[1,5,4- de][1,4]benzoxazine::US10464947, Example 193A::US9624241, Example 193A

SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN4CCC[C@H]4C3)n3[C@H](COc1c23)c1ccccn1

InChI Key InChIKey=WKAPWJJIVIHBPA-PGRDOPGGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318664   

TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318664((4S)-7-(3,5-dimethylisoxazol-4-yl)-2- [(8aS)-hexah...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM318664((4S)-7-(3,5-dimethylisoxazol-4-yl)-2- [(8aS)-hexah...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM318664((4S)-7-(3,5-dimethylisoxazol-4-yl)-2- [(8aS)-hexah...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM318664((4S)-7-(3,5-dimethylisoxazol-4-yl)-2- [(8aS)-hexah...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent