BDBM318711 N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridin-2-yl-4,5- dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}- 2-methoxyacetamide::US10464947, Example 241::US11498926, Example 242::US9624241, Example 241

SMILES COCC(=O)NC1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23

InChI Key InChIKey=WOHOURHICHJDOF-JOCHJYFZSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 318711   

TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [353-454](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:Table 12: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [58-164](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:Table 11: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [353-454](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:Table 12: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [58-164](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:Table 11: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318711(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent