BDBM318936 US10173988, Compound A

SMILES COc1cccc(c1)N1CCN(Cc2nc(N)nc(Nc3ccc(C)c(C)c3)n2)CC1

InChI Key InChIKey=STKSULQULJWEMU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318936   

TargetNADPH oxidase 1(Homo sapiens (Human))
Glucox Biotech

US Patent
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  6.60E+4nMAssay Description:CHO cells modified to stably express human Nox1 were grown in DMEM/F12 gibco 31331 containing 10% FBS and 1% pen/strep at 37° C. in air with 5% CO2. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Glucox Biotech

US Patent
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  1.68E+3nMAssay Description:Cells: Human blood was purchased in buffy coat, prepared the same day for isolation of neutrophils, from Labjoy AB, Lund, Sweden. Blood components we...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNADPH oxidase 3(Homo sapiens)
Monash University Malaysia

Curated by ChEMBL
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human NOX3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADPH oxidase 1(Homo sapiens (Human))
Glucox Biotech

US Patent
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NOX1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Glucox Biotech

US Patent
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human NOX2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADPH oxidase 4(Homo sapiens (Human))
Glucox Biotech

US Patent
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  1.68E+3nMAssay Description:Cells: HEK (CJ Nox4) stably expressing Nox4 was purchased from Redoxis AB (Lund). The adherent cells were cultivated in RPMI 1640 with L-Glutamine we...More data for this Ligand-Target Pair
In DepthDetails US Patent