BDBM319581 1-(((2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxy-N-methylisoquinoline-6-carboxamide::US10174000, Example 33

SMILES CNC(=O)c1nc2ccnc(OC[C@H]3NC(=O)[C@@H](F)[C@H]3C)c2cc1OC

InChI Key InChIKey=WKFUEMWSFHKSLG-KDDOJWQBSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319581   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM319581(1-(((2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent