BDBM320518 2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrrolidin-2-yl]ethyl}-6-(morpholin-4-yl)-9H-purine-8-carboxamide::US10174035, Compound 64

SMILES CN1CCCC1CCNC(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320518   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM320518(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Affinity DataIC50:  17nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM320518(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Affinity DataIC50:  984nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM320518(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Affinity DataIC50:  17nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM320518(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Affinity DataIC50:  6.13E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM320518(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Affinity DataIC50: >1.00E+4nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent