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BDBM321162 US10174049, Example 29::US9738658, Example 29

SMILES: COc1cc(C)ccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O

InChI Key: InChIKey=BJVIODZMEKECQW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321162   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
hdgat le


(Homo sapiens (Human))
BDBM321162
PNG
(US10174049, Example 29 | US9738658, Example 29)
Show SMILES COc1cc(C)ccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H21N5O3/c1-14-3-5-18(19(11-14)30-2)28-8-7-15-12-16(4-6-17(15)28)27-9-10-31-22-20(23(27)29)21(24)25-13-26-22/h3-8,11-13H,9-10H2,1-2H3,(H2,24,25,26)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321162
PNG
(US10174049, Example 29 | US9738658, Example 29)
Show SMILES COc1cc(C)ccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H21N5O3/c1-14-3-5-18(19(11-14)30-2)28-8-7-15-12-16(4-6-17(15)28)27-9-10-31-22-20(23(27)29)21(24)25-13-26-22/h3-8,11-13H,9-10H2,1-2H3,(H2,24,25,26)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair