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BDBM321163 US10174049, Example 30::US9738658, Example 30

SMILES: Nc1ncnc2OCCN(c3ccc4n(ccc4c3)C3CCOCC3)C(=O)c12

InChI Key: InChIKey=YKQXNKKLCKHDMN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321163   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
hdgat le


(Homo sapiens (Human))
BDBM321163
PNG
(US10174049, Example 30 | US9738658, Example 30)
Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)C3CCOCC3)C(=O)c12
Show InChI InChI=1S/C20H21N5O3/c21-18-17-19(23-12-22-18)28-10-7-25(20(17)26)15-1-2-16-13(11-15)3-6-24(16)14-4-8-27-9-5-14/h1-3,6,11-12,14H,4-5,7-10H2,(H2,21,22,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321163
PNG
(US10174049, Example 30 | US9738658, Example 30)
Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)C3CCOCC3)C(=O)c12
Show InChI InChI=1S/C20H21N5O3/c21-18-17-19(23-12-22-18)28-10-7-25(20(17)26)15-1-2-16-13(11-15)3-6-24(16)14-4-8-27-9-5-14/h1-3,6,11-12,14H,4-5,7-10H2,(H2,21,22,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair