BDBM321228 US10179123, Example 2-37

SMILES C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(cc2)C(C)(C)C)nc2cc(ccc12)C(O)=O

InChI Key InChIKey=HWRKDZZHVKWXAS-PGRDOPGGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321228   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM321228(US10179123, Example 2-37)
Affinity DataIC50:  50nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent