BDBM321257 US10179123, Reference compound 2-4-4

SMILES COC(=O)c1ccc2n([C@@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)[C@@H](C)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=RAIJWIZTJZLJES-FUHIMQAGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321257   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM321257(US10179123, Reference compound 2-4-4)
Affinity DataIC50: >1.00E+4nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent