BDBM321257 US10179123, Reference compound 2-4-4
SMILES COC(=O)c1ccc2n([C@@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)[C@@H](C)c1ccc(OC(F)(F)F)cc1
InChI Key InChIKey=RAIJWIZTJZLJES-FUHIMQAGSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 321257
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair