BDBM321291 N-(1-acryloylpiperidin-4-yl)-5- cyclopropylisoxazole-3-carboxamide::US10179773, Compound 5::US10669243, Compound 5

SMILES C=CC(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=WZFISHKVFZBXFE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321291   

TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM321291(N-(1-acryloylpiperidin-4-yl)-5- cyclopropylisoxazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM321291(N-(1-acryloylpiperidin-4-yl)-5- cyclopropylisoxazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent