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BDBM321356 6-but-2-enyl-4-(4-isopropylphenyl)-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 31

SMILES: CC=CCn1cc(-c2ccc(cc2)C(C)C)c2cc[nH]c2c1=O

InChI Key: InChIKey=JHFAQCYQGIFYIT-SNAWJCMRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321356   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM321356
PNG
(6-but-2-enyl-4-(4-isopropylphenyl)-1H-pyrrolo[2,3-...)
Show SMILES CC=CCn1cc(-c2ccc(cc2)C(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H22N2O/c1-4-5-12-22-13-18(17-10-11-21-19(17)20(22)23)16-8-6-15(7-9-16)14(2)3/h4-11,13-14,21H,12H2,1-3H3/b5-4+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair