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BDBM321358 3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N-isopropyl-benzamide::US10183009, Example 35

SMILES: CC=CCn1cc(-c2cccc(c2)C(=O)NC(C)C)c2cc[nH]c2c1=O

InChI Key: InChIKey=FAZRFOGZJHPCHE-SNAWJCMRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321358   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM321358
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES CC=CCn1cc(-c2cccc(c2)C(=O)NC(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H23N3O2/c1-4-5-11-24-13-18(17-9-10-22-19(17)21(24)26)15-7-6-8-16(12-15)20(25)23-14(2)3/h4-10,12-14,22H,11H2,1-3H3,(H,23,25)/b5-4+
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 720n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair