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BDBM322183 3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(piperidin-4-yl)benzamide HCl salt::US10183931, Example 22

SMILES: O=C(NC1CCNCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1

InChI Key: InChIKey=NCDYWCMXEYRYBW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322183   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322183
PNG
(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(pi...)
Show SMILES O=C(NC1CCNCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O/c31-23(28-18-6-9-24-10-7-18)16-3-1-2-15(12-16)22-25-11-8-21(29-22)27-19-4-5-20-17(13-19)14-26-30-20/h1-5,8,11-14,18,24H,6-7,9-10H2,(H,26,30)(H,28,31)(H,25,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322183
PNG
(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(pi...)
Show SMILES O=C(NC1CCNCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O/c31-23(28-18-6-9-24-10-7-18)16-3-1-2-15(12-16)22-25-11-8-21(29-22)27-19-4-5-20-17(13-19)14-26-30-20/h1-5,8,11-14,18,24H,6-7,9-10H2,(H,26,30)(H,28,31)(H,25,27,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair