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BDBM322518 5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-dihydro-1H-1,8-naphthyridin-2-one::US10183939, Example 1

SMILES: O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc4ccccc4[nH]3)ccnc2N1

InChI Key: InChIKey=IBIUXLREEDJYHV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322518   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-RAF (Y340D Y341D)


(Homo sapiens (human))
BDBM322518
PNG
(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc4ccccc4[nH]3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3/c29-22-8-6-17-21(9-10-25-24(17)28-22)31-16-5-7-20-14(12-16)11-15(13-30-20)23-26-18-3-1-2-4-19(18)27-23/h1-5,7,9-10,12,15H,6,8,11,13H2,(H,26,27)(H,25,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<4n/an/an/an/an/an/a



Redx Pharma PLC

US Patent




US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322518
PNG
(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc4ccccc4[nH]3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3/c29-22-8-6-17-21(9-10-25-24(17)28-22)31-16-5-7-20-14(12-16)11-15(13-30-20)23-26-18-3-1-2-4-19(18)27-23/h1-5,7,9-10,12,15H,6,8,11,13H2,(H,26,27)(H,25,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<4n/an/an/an/an/an/a



Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair