BindingDB logo
myBDB logout

BDBM322581 US10183940, Example 33

SMILES: Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12

InChI Key: InChIKey=RMOIUIWYJUZFJM-UHFFFAOYSA-N

Data: 5 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 322581   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
21.7n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...


US Patent US10183940 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
8.62E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...


US Patent US10183940 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...


US Patent US10183940 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...


US Patent US10183940 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...


US Patent US10183940 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10183940 (2019)

More data for this
Ligand-Target Pair