BDBM322906 2-(1-(4-((4-(4-(2-fluoroethyl)piperazin-1- yl)phenyl)amino)-5-oxo-5,6- dihydropyrimido[4,5-d]pyridazin-2-yl) piperidin-4-yl)acetonitrile::US10183944, Example 276::US10647720, Ex. # 276

SMILES FCCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1

InChI Key InChIKey=VJANWUOQIRLQLV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322906   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322906(2-(1-(4-((4-(4-(2-fluoroethyl)piperazin-1- yl)phen...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322906(2-(1-(4-((4-(4-(2-fluoroethyl)piperazin-1- yl)phen...)
Affinity DataIC50:  30nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322906(2-(1-(4-((4-(4-(2-fluoroethyl)piperazin-1- yl)phen...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322906(2-(1-(4-((4-(4-(2-fluoroethyl)piperazin-1- yl)phen...)
Affinity DataIC50: <50nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent