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BDBM323041 (1R,2R)-N-(4-Oxo-4,5,6,7- tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-2- [4-(1H-pyrazol-5- yl)benzoyl]cyclohexanecarboxamide::US10183947, Example 24

SMILES: O=C(Nc1cnn2CCNC(=O)c12)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1ccn[nH]1

InChI Key: InChIKey=GVACXRJSSBFEPC-IAGOWNOFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 323041   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM323041
PNG
((1R,2R)-N-(4-Oxo-4,5,6,7- tetrahydropyrazolo[1,5-a...)
Show SMILES O=C(Nc1cnn2CCNC(=O)c12)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1ccn[nH]1
Show InChI InChI=1S/C23H24N6O3/c30-21(15-7-5-14(6-8-15)18-9-10-25-28-18)16-3-1-2-4-17(16)22(31)27-19-13-26-29-12-11-24-23(32)20(19)29/h5-10,13,16-17H,1-4,11-12H2,(H,24,32)(H,25,28)(H,27,31)/t16-,17-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 8.10n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US10183947 (2019)

More data for this
Ligand-Target Pair