BDBM323087 4-((trans-4-(4-chlorophenyl)piperidin-3-yl)methoxy)-3-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide::US9630929, Example 59

SMILES Fc1cc(ccc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1

InChI Key InChIKey=PWDWJKYTQFZCLL-MBIQTGHCSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 323087   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323087(4-((trans-4-(4-chlorophenyl)piperidin-3-yl)methoxy...)
Affinity DataIC50: <100nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323087(4-((trans-4-(4-chlorophenyl)piperidin-3-yl)methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323087(4-((trans-4-(4-chlorophenyl)piperidin-3-yl)methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323087(4-((trans-4-(4-chlorophenyl)piperidin-3-yl)methoxy...)
Affinity DataIC50:  8.60nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent