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BDBM323818 US10189809, Compound I-66

SMILES: Fc1ccccc1Cn1nc(cc1-c1cccs1)-c1ncccn1

InChI Key: InChIKey=LAFXQKZQVLIEGG-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 323818   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323818
PNG
(US10189809, Compound I-66)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1cccs1)-c1ncccn1
Show InChI InChI=1S/C18H13FN4S/c19-14-6-2-1-5-13(14)12-23-16(17-7-3-10-24-17)11-15(22-23)18-20-8-4-9-21-18/h1-11H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair