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BDBM323953 US10189809, Compound I-186

SMILES: Nc1nc(ncc1NC(=O)c1ccccc1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1

InChI Key: InChIKey=LJQPZCIWTUZKDM-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 323953   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323953
PNG
(US10189809, Compound I-186)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H18FN7O2/c25-17-9-5-4-8-16(17)14-32-20(24-27-10-11-34-24)12-18(31-32)22-28-13-19(21(26)30-22)29-23(33)15-6-2-1-3-7-15/h1-13H,14H2,(H,29,33)(H2,26,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair