BDBM324399 5-(tert-butyl)-N-((S)-8- (2-((1-ethyl-1H-pyrazol- 4-yl)amino)pyrimidin-4- yl)-2-((R*)- tetrahydrofuran-3-yl)- 2,3,4,5-tetrahydro-1H- benzo[c]azepin-5-yl)- 1,3,4-oxadiazole-2- carboxamide::US10189829, Compound 138::US10227341, Compound 138::US10961237, Compound 138::US11858926, Compound 138

SMILES CCn1cc(Nc2nccc(n2)-c2ccc3[C@H](CCN(Cc3c2)[C@@H]2CCOC2)NC(=O)c2nnc(o2)C(C)(C)C)cn1

InChI Key InChIKey=AGBQBYQPWRNPSF-RDGATRHJSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 324399   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen Ma

US Patent
LigandPNGBDBM324399(5-(tert-butyl)-N-((S)-8- (2-((1-ethyl-1H-pyrazol- ...)
Affinity DataIC50:  505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [14-552](Homo sapiens (Human))
Biogen Ma

US Patent
LigandPNGBDBM324399(5-(tert-butyl)-N-((S)-8- (2-((1-ethyl-1H-pyrazol- ...)
Affinity DataIC50:  505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen Ma

US Patent
LigandPNGBDBM324399(5-(tert-butyl)-N-((S)-8- (2-((1-ethyl-1H-pyrazol- ...)
Affinity DataIC50:  505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen Ma

US Patent
LigandPNGBDBM324399(5-(tert-butyl)-N-((S)-8- (2-((1-ethyl-1H-pyrazol- ...)
Affinity DataIC50: <1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent